Angiogenic factors and preeclampsia
G Steinberg, EV Khankin, SA Karumanchi - Thrombosis Research, 2009 - Elsevier
Preeclampsia/eclampsia is a major cause of maternal and fetal morbidity worldwide.
Although the etiology of preeclampsia is still unclear, the clinical phenotypes of
preeclampsia have been demonstrated to be related to high circulating levels of anti-
angiogenic proteins secreted by the placenta such as soluble Fms-like tyrosine kinase 1
(sFlt1) and soluble endoglin. Because, alterations in circulating sFlt1 and soluble endoglin
precede the onset of clinical disease, these factors may be useful to screen or identify …
Although the etiology of preeclampsia is still unclear, the clinical phenotypes of
preeclampsia have been demonstrated to be related to high circulating levels of anti-
angiogenic proteins secreted by the placenta such as soluble Fms-like tyrosine kinase 1
(sFlt1) and soluble endoglin. Because, alterations in circulating sFlt1 and soluble endoglin
precede the onset of clinical disease, these factors may be useful to screen or identify …