Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization
K Pilarczyk, KJE Sattler, O Galili, D Versari, ML Olson… - Atherosclerosis, 2008 - Elsevier
BACKGROUND AND PURPOSE: Placenta growth factor (PlGF) mediates angiogenesis and
inflammation, but its role in human atherosclerosis is unknown. This study was designed to
test the hypothesis that PlGF-expression in human atherosclerotic carotid plaques is related
to inflammation, vascularization and clinical plaque instability. METHODS: The expression of
PlGF, C-reactive protein (CRP) and CD40L was analyzed with Western blots in carotid
plaques of 60 patients. Cellular infiltration (CD68, CD3) and vascularization (von-Willebrand …
inflammation, but its role in human atherosclerosis is unknown. This study was designed to
test the hypothesis that PlGF-expression in human atherosclerotic carotid plaques is related
to inflammation, vascularization and clinical plaque instability. METHODS: The expression of
PlGF, C-reactive protein (CRP) and CD40L was analyzed with Western blots in carotid
plaques of 60 patients. Cellular infiltration (CD68, CD3) and vascularization (von-Willebrand …