Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery
K Hayashida, S DeGoes, R Curry… - The Journal of the …, 2007 - pubs.asahq.org
Background Gabapentin has been reported to inhibit various acute and chronic pain
conditions in animals and humans. Although the efficacy of gabapentin depends on the
alpha2delta subunit of voltage-gated calcium channels, its analgesic mechanisms in vivo
are still unknown. Here, the authors tested the role of spinal noradrenergic inhibition in
gabapentin's analgesia for postoperative pain. Methods Gabapentin was administered orally
and intracerebroventricularly to rats on the day after paw incision, and withdrawal threshold …
conditions in animals and humans. Although the efficacy of gabapentin depends on the
alpha2delta subunit of voltage-gated calcium channels, its analgesic mechanisms in vivo
are still unknown. Here, the authors tested the role of spinal noradrenergic inhibition in
gabapentin's analgesia for postoperative pain. Methods Gabapentin was administered orally
and intracerebroventricularly to rats on the day after paw incision, and withdrawal threshold …