Pain is the dominant symptom in osteoarthritis (OA) and sensitization may contribute to the
pain severity. This study investigated the role of sensitization in patients with painful knee
OA by measuring (1) pressure pain thresholds (PPTs);(2) spreading sensitization;(3)
temporal summation to repeated pressure pain stimulation;(4) pain responses after
intramuscular hypertonic saline; and (5) pressure pain modulation by heterotopic
descending noxious inhibitory control (DNIC). Forty-eight patients with different degrees of …