Context Chronic pain and depression are highly comorbid conditions, yet little is known
about the neurobiological basis of pain processing in major depressive disorder (MDD).
Objective To examine the neural substrates underlying anticipation and processing of heat
pain in a group of unmedicated young adults with current MDD. Design Functional magnetic
resonance neuroimaging data were collected during an event-related factorial experimental
pain paradigm. Painful and nonpainful heat stimuli were applied to the left volar forearm …