Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
SG Shimada, KA Shimada, JG Collins - European journal of pharmacology, 2006 - Elsevier
SG Shimada, KA Shimada, JG Collins
European journal of pharmacology, 2006•ElsevierWe examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-
Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal
injections of SLIGRL-NH2 (10–50 μg) evoked dose dependent scratching. This behavior
peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals
with a histamine H1 receptor antagonist, pyrilamine, blocked histamine induced scratching,
but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates …
Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal
injections of SLIGRL-NH2 (10–50 μg) evoked dose dependent scratching. This behavior
peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals
with a histamine H1 receptor antagonist, pyrilamine, blocked histamine induced scratching,
but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates …
We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10–50 μg) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals with a histamine H1 receptor antagonist, pyrilamine, blocked histamine induced scratching, but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates histamine independent itch.
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