[PDF][PDF] Identification and role of aldosterone receptors in the cardiovascular system
M Lombes, N Farman, JP Bonvalet… - Annales d …, 2000 - academia.edu
M Lombes, N Farman, JP Bonvalet, MC Zennaro
Annales d Endocrinologie, 2000•academia.eduThe cardiovascular system is now recognized as an important mineralocorticoid target. All
components required for specific and selective aldosterone effects are present in the
cardiovascular system. Mineralocorticoid receptors (MR) are expressed in the heart and
large blood vessels together with the 11 β-hydroxysteroid dehydrogenase type II, which
ensures the enzymatic protection of MR against glucocorticoids. The recent description of
local vascular and cardiac aldosterone biosynthesis strongly supports an …
components required for specific and selective aldosterone effects are present in the
cardiovascular system. Mineralocorticoid receptors (MR) are expressed in the heart and
large blood vessels together with the 11 β-hydroxysteroid dehydrogenase type II, which
ensures the enzymatic protection of MR against glucocorticoids. The recent description of
local vascular and cardiac aldosterone biosynthesis strongly supports an …
The cardiovascular system is now recognized as an important mineralocorticoid target. All components required for specific and selective aldosterone effects are present in the cardiovascular system. Mineralocorticoid receptors (MR) are expressed in the heart and large blood vessels together with the 11 β-hydroxysteroid dehydrogenase type II, which ensures the enzymatic protection of MR against glucocorticoids. The recent description of local vascular and cardiac aldosterone biosynthesis strongly supports an autocrine/paracrine hormonal action. Establishment of transgenic mice models of targeted overexpression of the mineralocorticoid receptor should facilitate new insights into the molecular and cellular mechanisms of aldosterone actions in the cardiovascular system.
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