Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Nature genetics, 2008•nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387
cases and 6,209 controls and identified a region of strong association (rs10994336, P= 9.1×
10− 9) in ANK3 (ankyrin G). We also found further support for the previously reported
CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P=
7.0× 10− 8, rs1006737). Our results suggest that ion channelopathies may be involved in the
pathogenesis of bipolar disorder.
cases and 6,209 controls and identified a region of strong association (rs10994336, P= 9.1×
10− 9) in ANK3 (ankyrin G). We also found further support for the previously reported
CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P=
7.0× 10− 8, rs1006737). Our results suggest that ion channelopathies may be involved in the
pathogenesis of bipolar disorder.
Abstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10−9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10−8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
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