[CITATION][C] Pharmacology of a new adrenergic beta-receptor-blocking compound (Nethalide)
JW Black, JS Stephenson - The Lancet, 1962 - Elsevier
JW Black, JS Stephenson
The Lancet, 1962•ElsevierResults Effects of Compound 38,174 on Isolated Tissues The adrenergic blocking actions of
compound 38,174 were investigated in a series of isolated tissue preparations by means of
conventional in-vitro techniques. In these experiments replicated 3-point dose-response
curves to adrenaline were obtained in the presence of at least two different concentrations of
antagonist; the results are summarised in the table. Highly active blockade was only found
on those tissues which have been classified as containing adrenergic beta receptors.
compound 38,174 were investigated in a series of isolated tissue preparations by means of
conventional in-vitro techniques. In these experiments replicated 3-point dose-response
curves to adrenaline were obtained in the presence of at least two different concentrations of
antagonist; the results are summarised in the table. Highly active blockade was only found
on those tissues which have been classified as containing adrenergic beta receptors.
Results
Effects of Compound 38,174 on Isolated Tissues The adrenergic blocking actions of compound 38,174 were investigated in a series of isolated tissue preparations by means of conventional in-vitro techniques. In these experiments replicated 3-point dose-response curves to adrenaline were obtained in the presence of at least two different concentrations of antagonist; the results are summarised in the table. Highly active blockade was only found on those tissues which have been classified as containing adrenergic beta receptors.
Elsevier