[HTML][HTML] Specific role of the truncated βIV-spectrin Σ6 in sodium channel clustering at axon initial segments and nodes of Ranvier
Y Uemoto, S Suzuki, N Terada, N Ohno, S Ohno… - Journal of biological …, 2007 - ASBMB
At axon initial segments and nodes of Ranvier in neurons, the spectrin membrane skeleton
plays roles in physically stabilizing the plasma membrane integrity and in clustering voltage-
gated sodium channels for proper conduction of the action potential. βIV-Spectrin, an
essential component of the membrane skeleton at these sites, has an N-terminal-truncated
isoform, Σ6, which is expressed at much higher levels than the full-length isoform Σ1. To
investigate the role of βIV-spectrin Σ6, we generated Σ1-deficient mice with a normal level of …
plays roles in physically stabilizing the plasma membrane integrity and in clustering voltage-
gated sodium channels for proper conduction of the action potential. βIV-Spectrin, an
essential component of the membrane skeleton at these sites, has an N-terminal-truncated
isoform, Σ6, which is expressed at much higher levels than the full-length isoform Σ1. To
investigate the role of βIV-spectrin Σ6, we generated Σ1-deficient mice with a normal level of …