Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.

RM Zinkernagel - 1978 - cabidigitallibrary.org
RM Zinkernagel
1978cabidigitallibrary.org
This review of recent work includes consideration of H-2-linked immune response gene
expression in chimaeric mice and discussion of the practical implications of the relationship
of H-2 polymorphism with disease susceptibility. The experiments reviewed demonstrate,
inter alia, that the same MHC region probably codes for gene products which both restrict
and regulate T cell immune responses.
Abstract
This review of recent work includes consideration of H-2-linked immune response gene expression in chimaeric mice and discussion of the practical implications of the relationship of H-2 polymorphism with disease susceptibility. The experiments reviewed demonstrate, inter alia, that the same MHC region probably codes for gene products which both restrict and regulate T cell immune responses.
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