Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia
T Saarelainen, JA Lukkarinen, S Koponen… - Molecular and Cellular …, 2000 - Elsevier
It has been suggested that the increased production of endogenous BDNF after brain insults
supports the survival of injured neurons and limits the spread of the damage. In order to test
this hypothesis experimentally, we have produced transgenic mouse lines that overexpress
the dominant-negative truncated splice variant of BDNF receptor trkB (trkB. T1) in postnatal
cortical and hippocampal neurons. When these mice were exposed to transient focal
cerebral ischemia by occluding the middle cerebral artery for 45 min and the damage was …
supports the survival of injured neurons and limits the spread of the damage. In order to test
this hypothesis experimentally, we have produced transgenic mouse lines that overexpress
the dominant-negative truncated splice variant of BDNF receptor trkB (trkB. T1) in postnatal
cortical and hippocampal neurons. When these mice were exposed to transient focal
cerebral ischemia by occluding the middle cerebral artery for 45 min and the damage was …