Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection
W Scheurlen, K Ramasubbu, O Wachowski… - Journal of clinical …, 2001 - Elsevier
Objective: We report an 11-year-old boy presenting with splenomegaly, chronic
thrombocytopenia and concordant neutropenia. Results: In contrast to autoantibodies
against platelets, there were no detectable neutrophil-specific autoantibodies present in this
patient. Extensive serologic investigations revealed increased IgM-and IgG-antibody titers
against parvovirus B19. A nested polymerase chain reaction (PCR) showed parvovirus B19-
specific sequences in the patient's bone-marrow cells but not in the serum. Specific …
thrombocytopenia and concordant neutropenia. Results: In contrast to autoantibodies
against platelets, there were no detectable neutrophil-specific autoantibodies present in this
patient. Extensive serologic investigations revealed increased IgM-and IgG-antibody titers
against parvovirus B19. A nested polymerase chain reaction (PCR) showed parvovirus B19-
specific sequences in the patient's bone-marrow cells but not in the serum. Specific …