[HTML][HTML] Distinct phosphorylation events regulate p130-and p107-mediated repression of E2F-4
T Farkas, K Hansen, K Holm, J Lukas… - Journal of Biological …, 2002 - ASBMB
The" pocket proteins" pRb (retinoblastoma tumor suppressor protein), p107, and p130
regulate cell proliferation via phosphorylation-sensitive interactions with E2F transcription
factors and other proteins. We previously identified 22 in vivo phosphorylation sites in
human p130, including three sites selectively targeted by cyclin D-Cdk4 (6) kinases. Here
we assessed the effects of alanine substitution at the individual or combined Cdk4 (6)-
specific sites in p130, compared with homologous sites in p107 (Thr 369/Ser 650/Ser 964) …
regulate cell proliferation via phosphorylation-sensitive interactions with E2F transcription
factors and other proteins. We previously identified 22 in vivo phosphorylation sites in
human p130, including three sites selectively targeted by cyclin D-Cdk4 (6) kinases. Here
we assessed the effects of alanine substitution at the individual or combined Cdk4 (6)-
specific sites in p130, compared with homologous sites in p107 (Thr 369/Ser 650/Ser 964) …