Decreased synthesis and delayed processing of sulfated glycoproteins by cells from human polycystic kidneys.
FA Carone, H Jin, S Nakamura… - … Investigation; a Journal …, 1993 - europepmc.org
FA Carone, H Jin, S Nakamura, YS Kanwar
Laboratory Investigation; a Journal of Technical Methods and Pathology, 1993•europepmc.orgBackground In polycystic kidney disease, there is progressive distention of tubules and
remodeling of an altered extracellular matrix. Recent findings indicate a defect (s) in the
synthesis, post-translational modification, cellular transport, and extracellular matrix
incorporation of proteoglycans in PKD that may have a fundamental role in its pathogenesis.
remodeling of an altered extracellular matrix. Recent findings indicate a defect (s) in the
synthesis, post-translational modification, cellular transport, and extracellular matrix
incorporation of proteoglycans in PKD that may have a fundamental role in its pathogenesis.
Background
In polycystic kidney disease, there is progressive distention of tubules and remodeling of an altered extracellular matrix. Recent findings indicate a defect (s) in the synthesis, post-translational modification, cellular transport, and extracellular matrix incorporation of proteoglycans in PKD that may have a fundamental role in its pathogenesis.
europepmc.org