Growth factor gene expression in kidney of murine polycystic kidney disease.
T Nakamura, I Ebihara, I Nagaoka… - Journal of the …, 1993 - journals.lww.com
The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears
similar in many respects to that seen in the autosomal dominant form of human polycystic
kidney disease. The aim of this study was to examine the mRNA expression of growth-
related proteins in kidney obtained from DBA/2FG-pcy mice and control DBA/2 mice at 8, 16,
and 30 wk of age. The mRNA levels encoding for proliferating cell nuclear antigen (PCNA),
transforming growth factor (TGF)-beta, platelet-derived growth factor (PDGF)-A and PDGF-B …
similar in many respects to that seen in the autosomal dominant form of human polycystic
kidney disease. The aim of this study was to examine the mRNA expression of growth-
related proteins in kidney obtained from DBA/2FG-pcy mice and control DBA/2 mice at 8, 16,
and 30 wk of age. The mRNA levels encoding for proliferating cell nuclear antigen (PCNA),
transforming growth factor (TGF)-beta, platelet-derived growth factor (PDGF)-A and PDGF-B …