Differential growth factor-induced modulation of proteoglycans synthesized by normal human renal versus cyst-derived cells.
J Kovacs, FA Carone, ZZ Liu, S Nakumara… - Journal of the …, 1994 - journals.lww.com
In polycystic kidney disease (PKD), there is an insiduous enlargement of the kidneys and
dilation of the renal tubules associated with extracellular matrix (ECM) alterations. The latter
include thickening of tubular basement membrane and decreased synthesis of sulfated
proteoglycan (PG). Because PKD is believed to be a disorder of cell growth and deranged
ECM metabolism, it is conceivable that the formation of cystic tubules may be modulated by
certain growth factors (GF) that influence the synthesis of ECM glycoproteins. In this study …
dilation of the renal tubules associated with extracellular matrix (ECM) alterations. The latter
include thickening of tubular basement membrane and decreased synthesis of sulfated
proteoglycan (PG). Because PKD is believed to be a disorder of cell growth and deranged
ECM metabolism, it is conceivable that the formation of cystic tubules may be modulated by
certain growth factors (GF) that influence the synthesis of ECM glycoproteins. In this study …