[HTML][HTML] Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome [s]
R Marfella, C Di Filippo, M Portoghese, M Barbieri… - Journal of lipid …, 2009 - ASBMB
We evaluated the role of sterol-regulatory element binding protein (SREBP)-1c/peroxisome
proliferator activated receptor-γ (PPARγ) pathway on heart lipotoxicity in patients with
metabolic syndrome (MS) and aortic stenosis (AS). Echocardiographic parameters of heart
function and structural alterations of LV specimens were studied in patients with (n= 56) and
without (n= 61) MS undergoing aortic valve replacement. Tissues were stained with
hematoxylin-eosin (H and E) and oil red O for evidence of intramyocyte lipid accumulation …
proliferator activated receptor-γ (PPARγ) pathway on heart lipotoxicity in patients with
metabolic syndrome (MS) and aortic stenosis (AS). Echocardiographic parameters of heart
function and structural alterations of LV specimens were studied in patients with (n= 56) and
without (n= 61) MS undergoing aortic valve replacement. Tissues were stained with
hematoxylin-eosin (H and E) and oil red O for evidence of intramyocyte lipid accumulation …