Cyclosporine a slows the progressive renal disease of alport syndrome (X-linked hereditary nephritis): results from a canine model
D Chen, B Jefferson, SJ Harvey, K Zheng… - Journal of the …, 2003 - journals.lww.com
Alport syndrome refers to a hereditary disorder characterized by progressive renal disease
and a multilaminar appearance to the glomerular basement membrane (GBM). In a small
group of patients with Alport syndrome, cyclosporine A was reported to decrease proteinuria
and maintain stable renal function over 7 to 10 yr of follow-up. The present study examined
the effect of cyclosporine A on GBM structure and the progression to renal failure in a canine
model of X-linked Alport syndrome. Affected male dogs and normal male dogs treated with …
and a multilaminar appearance to the glomerular basement membrane (GBM). In a small
group of patients with Alport syndrome, cyclosporine A was reported to decrease proteinuria
and maintain stable renal function over 7 to 10 yr of follow-up. The present study examined
the effect of cyclosporine A on GBM structure and the progression to renal failure in a canine
model of X-linked Alport syndrome. Affected male dogs and normal male dogs treated with …