[HTML][HTML] Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells
NS Joo, DJ Lee, KM Winges, A Rustagi… - Journal of Biological …, 2004 - ASBMB
Airway submucosal gland serous cells express the cystic fibrosis transmembrane
conductance regulator (CFTR) and secrete antimicrobial, anti-inflammatory, and antioxidant
molecules. In cystic fibrosis, diminished gland secretion may impair innate airway host
defenses. We used Calu-3 cells as a serous cell model to study the types of proteins
released, the pathways that release them, and the possible involvement of CFTR activity in
protein release. Many proteins were secreted constitutively into the apical fluid and showed …
conductance regulator (CFTR) and secrete antimicrobial, anti-inflammatory, and antioxidant
molecules. In cystic fibrosis, diminished gland secretion may impair innate airway host
defenses. We used Calu-3 cells as a serous cell model to study the types of proteins
released, the pathways that release them, and the possible involvement of CFTR activity in
protein release. Many proteins were secreted constitutively into the apical fluid and showed …