α1-antitrypsin deficiency in 26-year-old subjects: lung, liver, and protease/protease inhibitor studies
E Piitulainen, J Carlson, K Ohlsson, T Sveger - Chest, 2005 - Elsevier
Background Clinical and biochemical signs of lung and liver disease have been followed
prospectively in a birth cohort of individuals with α 1-antitrypsin (AAT) deficiency. Objective
At age 26 years, the focus was on clinical health, lung and liver function tests, and plasma
markers of the protease/antiprotease balance. The effect of early childhood environment and
symptoms was also studied. Methods Eligible individuals were 26-year-old subjects with
AAT deficiency (PiZ, n= 122; PiZ−, n= 2; PiSZ/S−, n= 53) and control subjects (PiMM, n= 44) …
prospectively in a birth cohort of individuals with α 1-antitrypsin (AAT) deficiency. Objective
At age 26 years, the focus was on clinical health, lung and liver function tests, and plasma
markers of the protease/antiprotease balance. The effect of early childhood environment and
symptoms was also studied. Methods Eligible individuals were 26-year-old subjects with
AAT deficiency (PiZ, n= 122; PiZ−, n= 2; PiSZ/S−, n= 53) and control subjects (PiMM, n= 44) …