Liver transplantation is an important therapeutic option for many individuals with metabolic
liver disease. Nevertheless, the invasive nature of surgery and limitations of donor organ
availability have led to the search for alternatives to whole-organ transplantation. Cell-based
therapies have been a particularly active area of investigation in recent years. Hepatocyte
transplantations have been performed for a variety of indications, including acute liver
failure, end-stage liver disease, and inborn errors of metabolism. Individuals with inborn …