[HTML][HTML] Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock
J Xu, Y Ji, X Zhang, M Drake, CT Esmon - Journal of Thrombosis and …, 2009 - Elsevier
Summary Background: Activated protein C (APC) is known to protect animals from sepsis.
Endogenous protein C is important in protection. It is unknown whether the cytoprotective or
anticoagulant properties of protein C (PC) are responsible for the protective effect of
endogenous PC. Objective: To determine if signaling by endogenous activated protein C
contributes to survival in sepsis. Methods: We used an immunochemical approach to either
block all of the known activities of protein C using mAb MPC1609 or, alternatively …
Endogenous protein C is important in protection. It is unknown whether the cytoprotective or
anticoagulant properties of protein C (PC) are responsible for the protective effect of
endogenous PC. Objective: To determine if signaling by endogenous activated protein C
contributes to survival in sepsis. Methods: We used an immunochemical approach to either
block all of the known activities of protein C using mAb MPC1609 or, alternatively …