Unique functions of splenic CD8α+ dendritic cells during infection with intracellular pathogens

M Neuenhahn, DH Busch - Immunology letters, 2007 - Elsevier
Deciphering the prerequisites for the induction of protective cytotoxic T cell responses is
essential for future development of more effective CD8+ T cell-based vaccines against
infectious diseases and cancer. Since crucial events for CD8+ T cell priming and
differentiation occur during the first contacts of naïve T cells with distinct antigen-presenting
cells (APCs), the identification and therapeutic targeting of these 'master'APCs has become
a major quest in the field. A decade ago, dendritic cells (DCs) were discovered as potent …