Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway
DE Joyce, DR Nelson, BW Grinnell - Critical care medicine, 2004 - journals.lww.com
Objective: To give an overview of leukocyte and endothelial cell interactions in sepsis and to
explore the role of the protein C pathway in modulating the innate immune response via its
anti-inflammatory properties. Data Source: Novel in vitro data and a MEDLINE search for the
terms “activated protein C,”“recombinant human activated protein C,”“inflammation,”“
leukocyte adhesion,” and “sepsis” were used, along with clinical trial databases from the
PROWESS trial and a phase I human endotoxin trial evaluating recombinant human …
explore the role of the protein C pathway in modulating the innate immune response via its
anti-inflammatory properties. Data Source: Novel in vitro data and a MEDLINE search for the
terms “activated protein C,”“recombinant human activated protein C,”“inflammation,”“
leukocyte adhesion,” and “sepsis” were used, along with clinical trial databases from the
PROWESS trial and a phase I human endotoxin trial evaluating recombinant human …