[HTML][HTML] Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo

JL Frendo, G Xiao, S Fuchs, RT Franceschi… - Journal of Biological …, 1998 - ASBMB
Osteocalcin gene expression is initiated perinatally and is restricted to mature osteoblasts
and odontoblasts. Because their pattern of expression is highly restricted, the osteocalcin
genes are excellent tools to study osteoblast-specific gene expression. To define the
mechanisms of osteocalcin cell-specific gene expression in vivo, we generated transgenic
mice harboring deletion mutants of the promoter region of OG2, one of the mouse
osteocalcin genes. We show here that only 647 base pairs of this promoter are sufficient to …