RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes
Y Ito - Advances in cancer research, 2008 - Elsevier
Mouse embryonal carcinoma (EC) cells, also called teratocarcinoma stem cells, are
nonpermissive for polyomavirus growth, whereas differentiated derivatives of the cells are
permissive. Mutant viruses capable of growing in EC cells can be isolated. They have
genomic alterations within the viral enhancer, which is required for viral gene expression
and DNA replication. This viral regulatory region was considered as a potential probe for
mouse cell differentiation. The 24‐bp‐long A element within the enhancer was identified as …
nonpermissive for polyomavirus growth, whereas differentiated derivatives of the cells are
permissive. Mutant viruses capable of growing in EC cells can be isolated. They have
genomic alterations within the viral enhancer, which is required for viral gene expression
and DNA replication. This viral regulatory region was considered as a potential probe for
mouse cell differentiation. The 24‐bp‐long A element within the enhancer was identified as …