Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye Study
Objective To identify genetic loci that control intraocular pressure (IOP). Methods We
performed a genomewide scan of IOP, using 486 pedigrees ascertained through a
population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using
the modified Haseman-Elston regression models and variance components linkage
analysis. Results Seven regions of interest were identified on chromosomes 2, 5, 6, 7, 12,
15, and 19. The novel linkage region on chromosome 19p had an empirical …
performed a genomewide scan of IOP, using 486 pedigrees ascertained through a
population-based cohort, the Beaver Dam Eye Study. Linkage analysis was performed using
the modified Haseman-Elston regression models and variance components linkage
analysis. Results Seven regions of interest were identified on chromosomes 2, 5, 6, 7, 12,
15, and 19. The novel linkage region on chromosome 19p had an empirical …