Exploitation of the mouse as a model for glaucoma has been advanced by the development
of methods to measure mouse intraocular pressure (IOP), identification of mutant mouse
strains in which IOP spontaneously increases, and the development of treatments to induce
elevated IOP. These developments enable investigations that directly test the influence of
specific gene product alterations on the progression of glaucoma. Moreover, new transgenic
mouse models have been produced with genetic mutations that parallel human gene …