New York Medical College, Department of Pharmacology, Valhalla, NY 10595 USA
lnflammation and many other pathological processes lead to increascd production of free
radicals that target critical macromolecules such as proteins, DNA and lipids. Structural
modifications of these molecules, induced by free radicals, typically result in alterations of
vital biochemical processes. Hydroxyl radical-initiated lipid peroxidation is known to
generate a variety of toxic oxidized lipids, many of which originate from polyunsaturated fatty …