Protective action of carotenoid pigments against photodynamic damage to liposomes
SM Anderson, NI Krinsky - Photochemistry and Photobiology, 1973 - Wiley Online Library
SM Anderson, NI Krinsky
Photochemistry and Photobiology, 1973•Wiley Online LibraryWhen liposomes (a model membrane system) are subjected to a dye‐sensitized photo‐
oxidation, lysis, as measured by glucose leakage or a change in light scattering, results.
Before lysis occurs, the membrane lipids undergo peroxidative damage, as determined by
the appearance of malondialdehyde. Carotenoids incorporated into the liposomal
membrane protect against both lipid peroxidation and liposomal lysis. Other 1O2 quenchers
and free radical absorbers also protect liposomes from photodynamic damage.
oxidation, lysis, as measured by glucose leakage or a change in light scattering, results.
Before lysis occurs, the membrane lipids undergo peroxidative damage, as determined by
the appearance of malondialdehyde. Carotenoids incorporated into the liposomal
membrane protect against both lipid peroxidation and liposomal lysis. Other 1O2 quenchers
and free radical absorbers also protect liposomes from photodynamic damage.
Abstract
When liposomes (a model membrane system) are subjected to a dye‐sensitized photo‐oxidation, lysis, as measured by glucose leakage or a change in light scattering, results. Before lysis occurs, the membrane lipids undergo peroxidative damage, as determined by the appearance of malondialdehyde. Carotenoids incorporated into the liposomal membrane protect against both lipid peroxidation and liposomal lysis. Other 1O2 quenchers and free radical absorbers also protect liposomes from photodynamic damage.
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