• The use of locally applied cyclosporine was investigated in the retinal S-antigen-induced
experimental autoimmune uveitis (EAU) model in Lewis rats. A 2% cyclosporine solution
applied topically four times a day for 14 days effectively prevented the expression of EAU.
This treatment, however, produced circulating cyclosporine levels in the therapeutic range.
Lower concentrations of cyclosporine applied topically did not produce therapeutic levels
and were not capable of reliably preventing disease. Intraocular levels of cyclosporine …