Sequence 168 to 177 of interphotoreceptor retinoid-binding protein (IRBP) is an antigenic epitope for autoreactive CD8 T cells in the B10RIII mouse
We previously demonstrated that a significant proportion of interphotoreceptor retinoid-
binding protein (IRBP)-specific uveitogenic T cells in the C57BL/6 mouse and Lewis rat
express CD8. The aims of this study were to determine whether some of the IRBP-specific T
cells in the B10RIII mouse also express CD8 and whether CD8 and CD4 IRBP-specific T
cells in the B10RIII mouse recognize a different or the same antigenic epitope. Our results
show that autoreactive CD8 T cells were abundant in B10RIII mice immunized with the …
binding protein (IRBP)-specific uveitogenic T cells in the C57BL/6 mouse and Lewis rat
express CD8. The aims of this study were to determine whether some of the IRBP-specific T
cells in the B10RIII mouse also express CD8 and whether CD8 and CD4 IRBP-specific T
cells in the B10RIII mouse recognize a different or the same antigenic epitope. Our results
show that autoreactive CD8 T cells were abundant in B10RIII mice immunized with the …