The association of HLA class II with pars planitis
S Oruc, BF Duffy, T Mohanakumar, HJ Kaplan - American journal of …, 2001 - Elsevier
S Oruc, BF Duffy, T Mohanakumar, HJ Kaplan
American journal of ophthalmology, 2001•ElsevierPURPOSE: To investigate the association of HLA class II alleles with pars planitis.
METHODS: Blood samples were obtained from 28 patients with pars planitis seen in the
Department of Ophthalmology and Visual Sciences and the Barnes Retina Institute at
Washington University, St. Louis, Missouri. RESULTS: HLA-DR15, one of the allelic
subtypes of HLA-DR2, was present in 18 (64.3%) of 28 patients vs. 10 (20%) of 50 controls
(OR= 7.20, CI= 2.28–23.20, P=. 0001). HLA-DR51 (HLA-DRB 5) was present in 16 (57.1%) …
METHODS: Blood samples were obtained from 28 patients with pars planitis seen in the
Department of Ophthalmology and Visual Sciences and the Barnes Retina Institute at
Washington University, St. Louis, Missouri. RESULTS: HLA-DR15, one of the allelic
subtypes of HLA-DR2, was present in 18 (64.3%) of 28 patients vs. 10 (20%) of 50 controls
(OR= 7.20, CI= 2.28–23.20, P=. 0001). HLA-DR51 (HLA-DRB 5) was present in 16 (57.1%) …
PURPOSE
To investigate the association of HLA class II alleles with pars planitis.
METHODS
Blood samples were obtained from 28 patients with pars planitis seen in the Department of Ophthalmology and Visual Sciences and the Barnes Retina Institute at Washington University, St. Louis, Missouri.
RESULTS
HLA-DR15, one of the allelic subtypes of HLA-DR2, was present in 18 (64.3%) of 28 patients vs. 10 (20%) of 50 controls (OR = 7.20, CI = 2.28–23.20, P = .0001). HLA-DR51 (HLA-DRB 5) was present in 16 (57.1%) of 28 patients vs. 6 (12%) of 50 controls (OR = 9.78, CI = 2.79–36.42, P = .0001). HLA-DR17 was present in eight (28.6%) of 28 patients vs. one (2%) of 50 controls (OR = 19.60, CI = 2.29–886.7, P = .0001).
CONCLUSION
Pars planitis is associated with an increased frequency of the HLA-DR2 suballele, -DR15, HLA-DR51, and HLA-DR17. These results suggest an immunogenic predisposition exists to pars planitis.
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