Failure of autoregulation and intraventricular haemorrhage in preterm infants
DWA Milligan - The Lancet, 1980 - Elsevier
DWA Milligan
The Lancet, 1980•ElsevierAbstract Changes in mean arterial blood-pressure produced in five sick newborn infants by
transfusion or exchange of blood products were accompanied by striking increases in
cerebral blood-flow. These increases imply a failure of autoregulation. Four of the infants
had a fatal intraventricular hæmorrhage within 12 h of the observed change in flow. This
suggests that the increase in flow precipitated the hæmorrhage.
transfusion or exchange of blood products were accompanied by striking increases in
cerebral blood-flow. These increases imply a failure of autoregulation. Four of the infants
had a fatal intraventricular hæmorrhage within 12 h of the observed change in flow. This
suggests that the increase in flow precipitated the hæmorrhage.
Abstract
Changes in mean arterial blood-pressure produced in five sick newborn infants by transfusion or exchange of blood products were accompanied by striking increases in cerebral blood-flow. These increases imply a failure of autoregulation. Four of the infants had a fatal intraventricular hæmorrhage within 12 h of the observed change in flow. This suggests that the increase in flow precipitated the hæmorrhage.
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