Abetalipoproteinemia and metastatic spinal cord glioblastoma
RP Newman, EJ Schaefer, CB Thomas… - Archives of …, 1984 - jamanetwork.com
• Abetalipoproteinemia (ABL [Bassen-Kornzweig syndrome]) is characterized by marked
hypolipidemia with absence of low-density lipoproteins, fat-soluble vitamin deficiency,
spinocerebellar ataxia, and retinitis pigmentosa. Our patient had ABL, severe neurologic
disease, and spinal cord malignancy, as well as disseminated CNS and extraneural
metastases. It is possible that patients with this disorder and long-standing fat-soluble
vitamin deficiency may have increased risk for CNS malignancy.
hypolipidemia with absence of low-density lipoproteins, fat-soluble vitamin deficiency,
spinocerebellar ataxia, and retinitis pigmentosa. Our patient had ABL, severe neurologic
disease, and spinal cord malignancy, as well as disseminated CNS and extraneural
metastases. It is possible that patients with this disorder and long-standing fat-soluble
vitamin deficiency may have increased risk for CNS malignancy.