[HTML][HTML] Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner
A Wicovsky, N Muller, N Daryab, R Marienfeld… - Journal of biological …, 2007 - ASBMB
In most cell types, tumor necrosis factor (TNF) induces a transient activation of the JNK
pathway. However, in NFκB-inhibited cells, TNF stimulates also a second sustained phase
of JNK activation, which has been implicated in cell death induction. In the present study, we
have analyzed the relationship of cell death induction, caspase activity, JNK, and NFκB
stimulation in the context of TNF signaling in four different cellular systems. In all cases,
NFκB inhibition enhanced TNF-induced cell death and primed most, but not all, cells for …
pathway. However, in NFκB-inhibited cells, TNF stimulates also a second sustained phase
of JNK activation, which has been implicated in cell death induction. In the present study, we
have analyzed the relationship of cell death induction, caspase activity, JNK, and NFκB
stimulation in the context of TNF signaling in four different cellular systems. In all cases,
NFκB inhibition enhanced TNF-induced cell death and primed most, but not all, cells for …