[HTML][HTML] Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
K Takahashi, T Sasaki, A Mammoto, K Takaishi… - Journal of Biological …, 1997 - ASBMB
The Rho GDP dissociation inhibitor (GDI) forms a complex with the GDP-bound form of the
Rho family small G proteins and inhibits their activation. The GDP-bound form complexed
with Rho GDI is not activated by the GDP/GTP exchange factor for the Rho family members,
suggesting the presence of another factor necessary for this activation. We have reported
that the Rho subfamily members regulate the ezrin/radixin/moesin (ERM)-CD44 system,
implicated in reorganization of actin filaments. Here we report that Rho GDI directly interacts …
Rho family small G proteins and inhibits their activation. The GDP-bound form complexed
with Rho GDI is not activated by the GDP/GTP exchange factor for the Rho family members,
suggesting the presence of another factor necessary for this activation. We have reported
that the Rho subfamily members regulate the ezrin/radixin/moesin (ERM)-CD44 system,
implicated in reorganization of actin filaments. Here we report that Rho GDI directly interacts …