Nav1. 1 is predominantly expressed in nodes of Ranvier and axon initial segments
A Duflocq, B Le Bras, E Bullier, F Couraud… - Molecular and Cellular …, 2008 - Elsevier
Aggregation of voltage-gated sodium (Nav) channels in the axon initial segment (AIS) and
nodes of Ranvier is essential for the generation and propagation of action potentials. From
the three Nav channel isoforms (Nav1. 1, Nav1. 2 and Nav1. 6) expressed in the adult CNS,
Nav1. 1 appears to play an important function since numerous mutations in its coding
sequence cause epileptic syndromes. Yet, its distribution is still controversial. Here we
demonstrate for the first time that in the adult CNS Nav1. 1 is expressed in nodes of Ranvier …
nodes of Ranvier is essential for the generation and propagation of action potentials. From
the three Nav channel isoforms (Nav1. 1, Nav1. 2 and Nav1. 6) expressed in the adult CNS,
Nav1. 1 appears to play an important function since numerous mutations in its coding
sequence cause epileptic syndromes. Yet, its distribution is still controversial. Here we
demonstrate for the first time that in the adult CNS Nav1. 1 is expressed in nodes of Ranvier …