Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans

X Xiang, Y Han, M Neuvonen… - Pharmacogenetics …, 2009 - journals.lww.com
Methods Fasting blood samples were drawn from 24 healthy volunteers with SLCO1B1 c.
388AA-c. 521TT (* 1A/* 1A) genotype, eight with c. 388GG-c. 521TT (* 1B/* 1B) genotype, 24
with c. 521TC genotype, and nine with c. 521CC genotype. Plasma concentrations of 15
endogenous bile acids, their synthesis marker, and cholesterol were determined by liquid
chromatography–tandem mass spectrometry. Results The concentrations of
ursodeoxycholic acid, glycoursodeoxycholic acid, chenodeoxycholic acid, and …