Diagnosis and management of female infertility

S Smith, SM Pfeifer, JA Collins - Jama, 2003 - jamanetwork.com
INFERTILITY, DEFINED AS 1 YEAR OF attempted conception without suc-cess, is one of the
most prevalent chronic health disorders involving young adults. 1 Affecting 6 million or more
US couples, infertility is clinically distinct from recurrent spontaneous pregnancy loss. 1
Since 1978, the management of female infertility has been transformed by in vitro fertilization
(IVF). Intracytoplasmic sperm injection (ICSI), first reported as an IVF laboratory technique in
1992, has similarly changed the management of male infertility. In vitro fertilization and ICSI …