Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression

T Lifsted, T Le Voyer, M Williams… - … journal of cancer, 1998 - Wiley Online Library
T Lifsted, T Le Voyer, M Williams, W Muller, A Klein‐Szanto, KH Buetow, KW Hunter
International journal of cancer, 1998Wiley Online Library
Metastasis is one of the most important and complex processes in human neoplastic
disease. A large number of both positive and negative events must occur to permit a tumor
cell to colonize a distant site successfully. To identify mouse strains that harbor dominant
genetic modifiers of this process, a strain survey was initiated utilizing a transgenic mouse
mammary tumor model that exhibits a high incidence of pulmonary metastases. The
transgenic animal was bred to 27 different inbred strains of mice and scored for the …
Abstract
Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was initiated utilizing a transgenic mouse mammary tumor model that exhibits a high incidence of pulmonary metastases. The transgenic animal was bred to 27 different inbred strains of mice and scored for the metastatic organ tropism and metastatic density. Thirteen strains were identified that had a statistically significant reduction in the numbers of pulmonary metastases. In addition, 10 strains were identified that altered the kinetics of induction of the primary mammary tumor. These strains will likely provide useful model systems for the analysis of genetic interactions in the initiation and progression of mammary adenocarcinomas. Int. J. Cancer 77:640–644, 1998. © 1998 Wiley‐Liss, Inc.
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