[HTML][HTML] Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors* s⃞
L Li, PA Thompson, RL Kitchens - Journal of lipid research, 2008 - ASBMB
Apolipoprotein E (apoE) plays important roles in lipid homeostasis, anti-inflammation, and
host defense. Since tissue apoE mRNA levels have been reported to decrease during
inflammatory responses, we were surprised to find that plasma apoE levels were
significantly elevated during septic infections in both humans and mice. This apparent
paradox was also observed during lipopolysaccharide-induced acute inflammation in mice:
plasma levels of apoE increased up to 4-fold despite sharply decreased apoE gene …
host defense. Since tissue apoE mRNA levels have been reported to decrease during
inflammatory responses, we were surprised to find that plasma apoE levels were
significantly elevated during septic infections in both humans and mice. This apparent
paradox was also observed during lipopolysaccharide-induced acute inflammation in mice:
plasma levels of apoE increased up to 4-fold despite sharply decreased apoE gene …