Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
JJ McIntire, SE Umetsu, O Akbari, M Potter… - Nature …, 2001 - nature.com
Nature immunology, 2001•nature.com
To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-
35, we examined congenic mice that differed at the homologous chromosomal segment. We
identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr
is genetically distinct from known cytokine genes and controls the development of airway
hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning
identified a gene family that encodes T cell membrane proteins (TIMs); major sequence …
35, we examined congenic mice that differed at the homologous chromosomal segment. We
identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr
is genetically distinct from known cytokine genes and controls the development of airway
hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning
identified a gene family that encodes T cell membrane proteins (TIMs); major sequence …
Abstract
To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy.
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