IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys
A Bree, FJ Schlerman, M Wadanoli… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Airway inflammation is a hallmark feature of asthma and a driver of airway
hyperresponsiveness. IL-13 is a key inducer of airway inflammation in rodent models of
respiratory disease, but a role for IL-13 has not been demonstrated in primates. OBJECTIVE:
We sought to test the efficacy of a neutralizing antibody to human IL-13 in a cynomolgus
monkey model of lung inflammation. METHODS: Using cynomolgus monkeys (Macaca
fascicularis) that are sensitized to Ascaris suum through natural exposure, we developed a …
hyperresponsiveness. IL-13 is a key inducer of airway inflammation in rodent models of
respiratory disease, but a role for IL-13 has not been demonstrated in primates. OBJECTIVE:
We sought to test the efficacy of a neutralizing antibody to human IL-13 in a cynomolgus
monkey model of lung inflammation. METHODS: Using cynomolgus monkeys (Macaca
fascicularis) that are sensitized to Ascaris suum through natural exposure, we developed a …