Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis
LE Lenox, T Kambayashi, M Okumura, C Prieto… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Lymphocyte cytosolic protein 2, also known as Src homology 2 domain-
containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76), is an essential adaptor
molecule in myeloid cells, where it regulates FcεRI-induced mast cell (MC) and FcγR-and
integrin-induced neutrophil (polymorphonuclear leukocyte [PMN]) functions. SLP-76
contains 3 N-terminal tyrosines at residues 112, 128, and 145 that together are critical for its
function. OBJECTIVE: We sought to explore the relative importance of tyrosines 112, 128 …
containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76), is an essential adaptor
molecule in myeloid cells, where it regulates FcεRI-induced mast cell (MC) and FcγR-and
integrin-induced neutrophil (polymorphonuclear leukocyte [PMN]) functions. SLP-76
contains 3 N-terminal tyrosines at residues 112, 128, and 145 that together are critical for its
function. OBJECTIVE: We sought to explore the relative importance of tyrosines 112, 128 …