Everolimus.
MB Atkins, U Yasothan… - Nature reviews Drug …, 2009 - search.ebscohost.com
MB Atkins, U Yasothan, P Kirkpatrick
Nature reviews Drug discovery, 2009•search.ebscohost.comEverolimus Page 1 Everolimus O O HO O N O O O O O OH O O O OH Gene expression a b
Growth factor Tyrosine kinase receptor Everolimus, temsirolimus Proliferation, cell survival,
angiogenesis PI3K PTEN AKT mTOR S6K1 4EBP (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,
32S,35R)-1,18- dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4(2-hydroxyethoxy)-3methoxycyclohexyl]-1
-methylethyl}-19,30-dimethoxy-15,17,21,23,29, 35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]
hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20pentaone; C53H83NO14; Mr = 958.2 fresh …
Growth factor Tyrosine kinase receptor Everolimus, temsirolimus Proliferation, cell survival,
angiogenesis PI3K PTEN AKT mTOR S6K1 4EBP (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,
32S,35R)-1,18- dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4(2-hydroxyethoxy)-3methoxycyclohexyl]-1
-methylethyl}-19,30-dimethoxy-15,17,21,23,29, 35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]
hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20pentaone; C53H83NO14; Mr = 958.2 fresh …
Abstract In March 2009, everolimus (Afinitor; Novartis), an inhibitor of mTOR, was approved by the US FDA for the treatment of patients with advanced kidney cancer.
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