[HTML][HTML] Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and …

LJC Jonk, S Itoh, CH Heldin, P ten Dijke… - Journal of Biological …, 1998 - ASBMB
Smad proteins have been identified as mediators of intracellular signal transduction by
members of the transforming growth factor-β (TGF-β) superfamily, which affect cell
proliferation, differentiation, as well as pattern formation during early vertebrate
development. Following receptor activation, Smads are assembled into heteromeric
complexes consisting of a pathway-restricted Smad and the common Smad4 that are
subsequently translocated into the nucleus where they are thought to play an important role …