Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice
AO Samokhin, A Wong, P Saftig, D Brömme - Atherosclerosis, 2008 - Elsevier
Cathepsin K, a potent extracellular matrix degrading cysteine protease, has been linked to
the pathogenesis of osteoporosis, arthritis, cardiovascular and respiratory diseases. Here,
we report the effects of cathepsin K deficiency (ctsK−/−) on atherosclerotic plaque formation
in brachiocephalic arteries in an aggressive atherosclerosis model using apoE-deficient
mice on cholate-containing high fat diet (HFD). On this diet, apoE−/− mice displayed severe
lesions with buried fibrous caps after 8 weeks, whereas the apoE−/− ctsK−/− mice revealed …
the pathogenesis of osteoporosis, arthritis, cardiovascular and respiratory diseases. Here,
we report the effects of cathepsin K deficiency (ctsK−/−) on atherosclerotic plaque formation
in brachiocephalic arteries in an aggressive atherosclerosis model using apoE-deficient
mice on cholate-containing high fat diet (HFD). On this diet, apoE−/− mice displayed severe
lesions with buried fibrous caps after 8 weeks, whereas the apoE−/− ctsK−/− mice revealed …