Forced swimming in rats: hypothermia, immobility and the effects of imipramine
RD Porsolt, M Deniel, M Jalfre - European Journal of Pharmacology, 1979 - Elsevier
RD Porsolt, M Deniel, M Jalfre
European Journal of Pharmacology, 1979•ElsevierRats when forced to swim in a restricted space not only became immobile but showed
marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro
4-1284 and was not antagonized by imipramine at doses which significantly reduced
immobility. Hypothermia induced by forced swimming can therefore be dissociated from the
immobility occurring in these conditions and also from drug-induced hypothermia.
marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro
4-1284 and was not antagonized by imipramine at doses which significantly reduced
immobility. Hypothermia induced by forced swimming can therefore be dissociated from the
immobility occurring in these conditions and also from drug-induced hypothermia.
Abstract
Rats when forced to swim in a restricted space not only became immobile but showed marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro 4-1284 and was not antagonized by imipramine at doses which significantly reduced immobility. Hypothermia induced by forced swimming can therefore be dissociated from the immobility occurring in these conditions and also from drug-induced hypothermia.
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